The results re-vealed that KRAS-mutant cells are selectively sensitive to ABT199 + IRIN combination compared to the KRAS wildtype cells.ģ.2. 1F) cells, the combination of ABT199 and IRIN showed obvious synergism as CI values were < 0.7 in both cases compared to KRAS-wt Bafilomycin A1 (Fig. ![]() We found that in KRAS mutant cells-H661 (Fig. We used ABT199 and IRIN in different concentrations and the effect of drug combination is de-termined by the CI values, with CI 1.10, antagonism. To detect the therapeutic effect of ABT199 + IRIN combination on lung cancer cells, we measured the combination indexes (CI) for various combinations of the two drugs administered. The combined ABT199 and IRIN in Mutant KRAS Lung Cancer Cells are sensitive Student's t-tests were performed to compare difference of the means between two groups. The data are presented as the mean ± SEM. ![]() Statistical analysis was carried out using GraphPad Prism v5.04 (GraphPad Software).
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